Hyaluronic acid [HA] is a fundamental element of the extracellular matrix. Due to its amazing capacity to retain water, HA is a highly desirable ingredient in moisturizing creams. Further, because HA can stimulate dermal fibroblast proliferation and migration, it is also ideal for use in wrinkle-reducing and anti-aging formulas. HA can be purchased at various molecular weights with different molecular weights eliciting different effects on the skin. For use in wound-healing support or restoring barrier function, high molecular weight is the best option. For the best results in anti-aging and moisturizing creams, low molecular weight HA is the ideal choice due to increased penetration of the HA through the skin.